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Molecules and Measurements Matter: Vitamin D optimization requires laboratory testing

Vitamin D supplementation: "It's not what you take, it's what you make." Dr Alex Vasquez

Your body responds to the balance and concentration of molecules, more so than to anything else; the strongest cause-effect relationships in biology and medicine are noted with molecules more than with nonphysical phenomena such as sleep and emotions, although those are obviously important.

As one of my naturopathic medicine and Oncology professors said,

“You cannot psychotherapy yourself out of depression caused by vitamin B12 deficiency.”

With regard to vitamin D, what matters is not how much you take, but rather how much you make—the resulting blood level of 25-hydroxy-vitaminD3.

I wrote the vitamin D paradigm shift in 2004, and this document remains the standard; in 2011 and 2021, I updated the optimal range

Dr Alex Vasquez 2004 2008 2024 Vitamin D 2008 Jcem Paradigm 2004 Jama 2004 Bmj 2005 Pharmacology 2024
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  1. Vasquez A, Manso G, Cannell J. The clinical importance of vitamin D (cholecalciferol): a paradigm shift with implications for all healthcare providers. Altern Ther Health Med. 2004 Sep-Oct;10(5):28-36

  2. Vasquez A, Cannell J. Calcium and vitamin D in preventing fractures: data are not sufficient to show inefficacy. BMJ. 2005 Jul 9;331(7508):108-9 https://pmc.ncbi.nlm.nih.gov/articles/PMC558659/

  3. Gordon CM, Williams AL, Feldman HA, May J, Sinclair L, Vasquez A, Cox JE. Treatment of hypovitaminosis D in infants and toddlers. J Clin Endocrinol Metab. 2008 Jul;93(7):2716-21. doi: 10.1210/jc.2007-2790. Epub 2008 Apr 15. PMID: 18413426; PMCID: PMC2729207. https://pmc.ncbi.nlm.nih.gov/articles/PMC2729207/

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Vitamin D (25ohD) laboratory interpretation:

“It’s not what you take, it’s what you make.” Dr Vasquez (2022)

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