VIDEO: Common VITAMIN D DEFICIENCY results in CHRONIC PAIN and PAIN AMPLIFICATION

Many people with CHRONIC PAIN and various PAIN SYNDROMES such as LOW-BACK PAIN, MIGRAINES and FIBROMYALGIA can achieve complete/partial alleviation of their pain by correcting this common deficiency

TWO UPDATES in 2026: 1) This page was updated in February 2026 to provide a new link to the video discussing how vitamin D deficiency causes and amplifies various types of pain. 2) Additionally, four (4) more videos have been included toward the bottom of this page specific to treatments and paradigms in chronic pain management.

Questions answered in this video:

• How does vitamin D deficiency result in chronic severe pain?

• What are the 3 main mechanisms by which vitamin D deficiency results in pain amplification and chronification?

• What are another 3-6 mechanisms by which deficiency of vitamin D results in pain amplification/chronification?

• How common is vitamin D deficiency?

• How is vitamin D deficiency treated, and what are the optimal levels of vitamin D as measured by the blood test 25-hydroxy-vitaminD?

VIDEO REVIEW: Vitamin D against Chronic Pain, Low-Back Pain, Migraine [GOLDMINE1]

• Author and presenter: Dr Alex Vasquez

• Production: Studio recording in high (1080) definition

• Date: March 2021

• Effort: Several years of study in basic sciences, clinical sciences, clinical practice, lecturing to post-graduate audiences internationally, research review, publication of major clinical monograph (Integrative Medicine 2004), summary letter (British Medical Journal 2005), letter on CRPS and fibromyalgia (Nature Reviews Rheumatology 2016) and many others available for free PDF download; please see “Compilation of Vitamin D articles and letters 2004-2020 by Dr Alex Vasquez” from ichnfm.academia.edu/AlexVasquez. Videos typically require 1 week of preparation, 2 hours of recording, and 8 hours of editing per finished hour of video.

Beyond my publications on vitamin D are my publications on chronic pain, migraine, and fibromyalgia

Chapter 5, Section 2 focuses on migraine headaches, which I assert originate from the additive/synergistic combination of mitochondrial dysfunction, glial activation, and neuroinflammation; as such, migraine and its related variant cluster headache can reasonably be categorized as manifestations of metabolic inflammation (primarily) resulting in neuroinflammation (secondarily). This work originated from my teaching notes (Orthopedics, Basty University, 2000) clinical textbooks (Integrative Orthopedics, 2004, 2012) and clinical monographs (Musculoskeletal Pain, 2008) and has been updated for more than 25 years of literature review and personal/clinical experience. My migraine and fibromyalgia protocols both received quantum leaps in their respective details and illustrations for the 2016 publication of Inflammation Mastery 4^th Edition, based on better understandings of metabolic and dysbiotic contributions to neuroinflammation in migraine and fibromyalgia, respectively. Also, very important to the further development of these understandings and protocols was my personal experience with dysbiosis-induced fibromyalgia starting in 1995 (and lasting for many years) and then later developing complex regional pain syndrome (CRPS) in 2020; my struggles with and permanent victories over both of these conditions attests to my understandings of these conditions, which is reflected in the descriptions illustrations, and protocols. Finally, of additional note are a few of my publications related to these topics (listed herein, below) and my 2-hour 2019 conference presentation on fibromyalgia which is archived online at HealthyThinking.substack.com/p/vasquez-fibromyalgia-protocol-2019 and InflammationMastery.substack.com/p/vasquez-fibromyalgia-protocol-houston.

1. Vasquez A. Biological plausibility of the gut-brain axis in autism. Ann N Y Acad Sci 2017 Nov

2. Vasquez A. Neuroinflammation in fibromyalgia and CRPS is multifactorial. Nat Rev Rheumatol 2016 Apr

3. Vasquez A. Mitochondrial Medicine Arrives to Prime Time in Clinical Care: Nutritional Biochemistry and Mitochondrial Hyperpermeability (”Leaky Mitochondria”) Meet Disease Pathogenesis and Clinical Interventions. Integr Med (Encinitas). 2014 Aug PMC4566442 also published in Altern Ther Health Med 2014 Winter

4. Vasquez A. Musculoskeletal Pain: Expanded Clinical Strategies. Commissioned and published by the Institute for Functional Medicine (IFM) in 2008

5. Vasquez A. Interventions [for pediatric migraine] need to be consistent with osteopathic philosophy. J Am Osteopath Assoc 2006 Sep

6. And of course much more detail and more clinical applications are detailed in INFLAMMATION MASTERY 4TH EDITION:

More/related information:

• free PDF download: Compilation of Vitamin D articles and letters 2004-2020 by Dr Alex Vasquez

• DrV’s website page dedicated to information on vitamin D: InflammationMastery.com/d

• Additional PDF downloads and video transcripts: ichnfm.academia.edu/AlexVasquez

Dr Alex Kennerly Vasquez (introduction; brief Bio-CV) writes and teaches for an international audience on various topics ranging from leadership to nutrition to functional inflammology. Major books include Inflammation Mastery, 4th Edition (full-color printing, 1182 pages, equivalent to 25 typical books [averaging 60,000 words each]), which was also published in two separate volumes as Textbook of Clinical Nutrition and Functional Medicine (Volume 1: Chapters 1-4; Volume 2: Chapter 5—Clinical Protocols for Diabetes, Hypertension, Migraine, Fibromyalgia, Rheumatoid Arthritis, Psoriasis, Vasculitis, Dermatomyositis and most other major inflammatory/autoimmune disorders); several sections have been excerpted including Antiviral Strategies and Immune Nutrition (ISBN 1502894890) (aka, Antiviral Nutrition [available as PDF download] and Brain Inflammation in Chronic Pain, Migraine, and Fibromyalgia. Dr Vasquez’s books are available internationally via bookstores such as BookDepository, Amazon.com, Barnes and Noble, ThriftBooks, AbeBooks, BetterWorldBooks, WaterStonesBooks and his new Telegram channel is https://t.me/DrAlexVasquez.