Failure by Route of Administration: Injected vaccines fail to produce robust mucosal immunity
Failure by Route of Administration: Injected vaccines fail to produce robust mucosal immunity
Most doctors have not trained in Immunology and Pharmacology in proportion to their prescribing scope; as such many of us were pressured to use (and receive) drugs that we don't fully understand.
PART ONE—Executive summary: Injected vaccines fail to produce mucosal IgA protection while creating the illusion of “protective immunity” (including protection against infection and transmission) via increased blood levels of IgG antibodies, which are easier to measure but of less clinical value
Details: The new experimental injected vaccines (which, by definition bypass mucosal surfaces of the eyes, nose, mouth, throat and respiratory tract) induce production of IgM and IgG antibodies without inducing production of IgA antibodies which are the main protection of mucosal surfaces of the eyes, nose, mouth, throat and respiratory tract. Thus, when used against respiratory viral infections, injected vaccines induce the wrong antibodies (IgM and IgG instead of IgA) in the wrong location (blood instead of mucosal surfaces) and thus fail to protect mucosal surfaces with IgA antibodies. Furthermore, because IgA antibodies trap/neutralize viruses before infection has occurred and because IgA antibodies lack the Fc “anchor”, they are simultaneously more effective at preventing infection and less likely to engage in antibody-dependent enhancement (ADE) whereby antibodies of other classes (eg, IgG) provide an entry mechanism for viruses to begin replication.
Citation: Chao et al. The role of IgA in COVID-19. Brain, Behavior, and Immunity. 2020 Jul 182-183 PDF provided here per open access agreement from publisher
PART TWO—Executive summary: Injected vaccines do not produce robust mucosal immunity and thus appear likely to increase asymptomatic transmission (fewer symptoms from infection but same high level of virus in the nose and throat)
Important quote: “Although viral vaccines generate cellular immunity with vaccine-specific memory CD4+ T helper 1 cells and CD8+ T cells, the principal mechanism by which injectable (eg, systemic) vaccines protect against respiratory infections is the development of humoral [blood] immunity through vaccine-specific serum [blood] IgG.1 … To effectively prevent viral replication within mucosal primary target cells, adequate local production of secretory IgA (SIgA) is necessary, which generally requires a mucosal route of vaccination.”
Important observation: The authors note that “viral titer endpoints” are NOT incorporated into vaccine trials, and this explodes a huge part of the propagandistic façade of vaccine promotion: these vaccines are sold to the public as providing protection and reducing transmission but in fact measuring of viral loads (“viral titer endpoints”) isn’t even part of most vaccine trials. In other words, they are selling the idea but without the data to support their claim.
Citation: Bleier et al. COVID-19 Vaccines May Not Prevent Nasal SARS-CoV-2 Infection and Asymptomatic Transmission. Otolaryngol Head Neck Surg 2021 Feb;164(2):305-307. doi: 10.1177/0194599820982633
Here’s what I think we could be doing to make all of this work better. For the sake of this discussion, we’re going to pretend that the vaccine paradigm is valid and useful:
1. Vaccines against viral infections (that are transmitted via mucosal routes) should be administered by mucosal routes in order to induce protective mucosal IgA responses. Failure of the injection route is an example of “primary vaccine failure” per my recent review of basic medical terminology.
2. Mucosal administration such as drops or spray into the nose would also avoid nearly all of the chemical and metal contaminants that are found in injected vaccines; this would create a much safer vaccine experience for patients.
3. We need to ensure that everyone has the proper nutrition to support immune defense and barrier (including IgA) function. See video below for a focus on vitamin D and barrier defense.
These super-cool summaries are not personalized medical advice.