IM4update (1) Fuel oxidation under control of mitochondrial shape and dynamics 2023
Update to IM4 = Inflammation Mastery, 4th Edition https://www.inflammationmastery.com/book
As I mentioned in the final few minutes of my recent video on iodide therapy and the 1965 publication-paradigm shift, I am already working on some new reviews of mitochondrial function (from the perspective of basic sciences) and neuroinflammation (from the perspective of clinical sciences), among other topics.
Variable length: Some of these articles are ginormous—up to 70 pages which is huge for a scientific article. Other articles such as the one posted here are a short 2-3 pages.
Variable complexity: Some of these articles are easy reading; others require days for review and understanding.
Variable applicability: Some of these articles never transition to clinical applicability while others are loaded with clinical ready-for-prime-time action steps.
Has the clinical paradigm shifted in any meaningful way?
For me, life is too short for idle reading. Furthermore, I have no intention of filling my books with molecular trivia even if I personally understand it and find it interesting. As such, my “IM4updates” will boil down to the singular evaluation of clinical utility:
How does this information change the way we treat patients either for 1) preventive healthcare or 2) specific diseases and disorders?
Some articles will be mildly interesting (at the very least, otherwise I would not take the time to read them and post them here) and others will hopefully be rich with detail that we can apply practically—let’s hope for more of the latter.
I have previously provided considerable detail on mitochondrial medicine/nutrition in:
Alex Vasquez, DC, ND, DO, FACN: Mitochondrial Dysfunction and the Emerging “Mitochondrial Medicine” Interview by Craig Gustafson. Integrative Medicine 2013 (PDF on ResearchGate)
Mitochondrial medicine arrives to prime time in clinical care: nutritional biochemistry and mitochondrial hyperpermeability ("leaky mitochondria") meet disease pathogenesis and clinical interventions. Altern Ther Health Med 2014 Winter;20 Suppl 1:26-30 (Full-text at Pubmed Central)
Chapter 4, section 4 of Inflammation Mastery, 4th Edition also published as Textbook of Clinical Nutrition and Functional Medicine, 2016
A few other articles and books, numerous CME presentations, and additional videos-articles here on HealthyThinking—you can search the archives for your topic of interest
I also published a very large book on mitochondrial nutrition that was very popular but was lost due to shenanigans at Amazon during the plandemic during the same timeframe that they disappeared my book on antiviral nutrition.
I’ve continued watching and waiting for new *clinically relevant* information to be published…
Today’s article is “Fuel oxidation under the control of mitochondrial shape and dynamics” published in 2023; here I’ll provide:
The full-text PDF (my personal copy with any notes or highlights) and
My commentary focused on answering the question “How does [assuming that it might, but might not] this information change the way we treat patients either for 1) preventive healthcare or 2) specific diseases and disorders?”
I suppose any article might be “game changing” for any particular reader and not for another; but all I can do is provide my personal perspective as someone with a good amount of experience and study in this area.