UPDATE Feb 2025: I’ve noticed that some of the videos previously posted/streaming from the Vimeo platform are no longer reliably visible, while at the same time, this Substack platform has progressively allowed for direct uploading/embedding of videos; as such, many of the previously-posted videos are being reloaded directly into the Substack platform for more reliable access and archiving.
Video #3: Prototypic Clinical Patterns of Dysbiosis-Induced Disease
Objectives and Clinical Importance:
Explain and demonstrate appropriate clinical management of the dysbiotic component of the listed prototypic conditions:
Dysbiotic encephalopathies:
Hepatic encephalopathy
D-lactic acidosis
Autobrewery syndrome—one of the irrefutable prototypes of dysbiosis wherein an intestinal overgrowth of yeast ferments dietary carbohydrate into ethanol, allowing persons to become inebriated “drunk” with alcohol despite no intentional/direct/oral intake of alcoholic beverages.
Fibromyalgia—this pain syndrome is well-known to be caused by SIBO, which results in mitochondrial dysfunction and activation of the NLRP3 inflammasome, resulting in neuroinflammation and central sensitization to pain
Atopic dermatitis / eczema—well-known to be proximally triggered by bacterial inflammogens and an IgE-mediated response to skin bacteria, especially Staphylococcus aureus
Insulin resistance and type-2 diabetes—causatively linked with an inflammatory dysbiosis as well as possible dermal overgrowth of Staphylococcus aureus
Psoriasis—well-known, thanks largely to the work of Dr Patricia Noah and colleagues, to be triggered by multifocal polydysbiosis
Bowel-associated dermatitis arthritis syndrome, short-bowel syndrome—a very elegant model of the effects of SIBO, resulting in multicomponent pathophysiology including generalized inflammation, immune-complex pathophysiology resulting in arthritis/dermatitis/vasculitis, and also cell-mediated bacterial allergy
Analyze/Interpret: Laboratory results for significance and/or lack thereof; judicious analysis
Identify: Actionable alterations in microbial patterns, phenotypes of dysbiosis-induced disease
Implement: Treatment plans consistent with the 4 main components of evidence-based medicine
Must be able to name and clinically apply a 3-pronged treatment plan addressing each of the 3 main components of dysbiosis
Clinical narrative: The information in this presentation completes the next step in our translation of molecules via pathophysiologic responses to various “patterns of inflammation” that distill into various clinical prototypes; by appreciating these prototypes, clinicians can see the clinical presentation of various patterns of dysbiosis-induced disease
My course on “Human Microbiome and Dysbiosis in Clinical Disease” was developed over several years starting formally in 2015-2017 as a continuing medical education (CME) postgraduate online conference joint-accredited for doctors, nurses, and pharmacists:
“American Medical Association Physician's Recognition Award (AMA PRA) Category 1 Statement: This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership … accredited by the ACCME to provide continuing medical education for physicians. …designates this educational activity for a maximum of 30 AMA PRA Category 1 credits.
Nursing Statement: …approved provider of continuing nursing education by the Washington State Nurses Association WSNA A-CNE, an accredited Approver of Continuing Nursing Education.
Pharmacy Statement: …accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. Objectives appropriate for pharmacists.”
I’ve established legitimate expertise on this topic for more than 20 years via clinical experience, post-graduate conference presentations, book publications, and numerous peer-reviewed professional publications.
Dr Alex Vasquez. Reducing pain and inflammation naturally - Part 6: Nutritional and Botanical Treatments Against “Silent Infections” and Gastrointestinal Dysbiosis, Commonly Overlooked Causes of Neuromusculoskeletal Inflammation and Chronic Health Problems. Nutritional Perspectives 2006 Jan
Dr Alex Vasquez. Neuroinflammation in fibromyalgia and CRPS is multifactorial. Nat Rev Rheumatol 2016 Apr;12(4):242. doi: 10.1038/nrrheum.2016.25 pubmed.ncbi.nlm.nih.gov/26935282
Dr Alex Vasquez. Biological plausibility of the gut-brain axis in autism. Ann N Y Acad Sci 2017 Nov;1408(1):5-6. doi: 10.1111/nyas.13516 pubmed.ncbi.nlm.nih.gov/29090837
Dr Alex Vasquez. Musculoskeletal Pain: Expanded Clinical Strategies: Printed monograph approved for ACCME PRA-1 Continuing Medical Education ncbi.nlm.nih.gov/nlmcatalog/101633549 Published by: Institute for Functional Medicine. 2008 May
Dr Alex Vasquez. Mitochondrial Medicine Arrives to Prime Time in Clinical Care: Nutritional Biochemistry and Mitochondrial Hyperpermeability ("Leaky Mitochondria") Meet Disease Pathogenesis and Clinical Interventions. Integr Med (Encinitas) 2014 Aug;13(4):44-9 pubmed.ncbi.nlm.nih.gov/26770108
Dr Alex Vasquez. Reply to "role of Western diet in inflammatory autoimmune diseases" by Manzel et al. In current allergy and asthma reports (volume 14, issue 1, January 2014). Curr Allergy Asthma Rep 2014 Aug;14(8):454. doi: 10.1007/s11882-014-0454-4 pubmed.ncbi.nlm.nih.gov/24947682
Dr Alex Vasquez. Correspondence regarding Cutshall, Bergstrom, Kalish's "Evaluation of a functional medicine approach to treating fatigue, stress, and digestive issues in women" in Complement Ther Clin Pract 2016 May. Complement Ther Clin Pract 2018 May;31:332-333. doi: 10.1016/j.ctcp.2016.10.001 pubmed.ncbi.nlm.nih.gov/27814977
Dr Alex Vasquez. The Microbiome Arrives to Prime Time in Primary Care, Implications for the Anti-Dysbiotic Treatment of Fibromyalgia. Nutritional Perspectives 2015 Oct
Dr Alex Vasquez. Translating Microbiome (Microbiota) and Dysbiosis Research into Clinical Practice: The 20-Year Development of a Structured Approach that Gives Actionable Form to Intellectual Concepts. International Journal of Human Nutrition and Functional Medicine 2015 Jun
