Vaccine studies need at least 5-7 years, according to NEJM 2016

Evidence of people becoming more vulnerable to infection following vaccination—just like we have already noted with the pertussis vaccines.

The real science shows us that we need at least 5-7 years to determine the real-world safety and effectiveness of vaccines, because an initially positive/beneficial effect might be offset by a negative/harmful effect later, as demonstrated in the study “Seven-Year Efficacy of RTS,S/AS01 Malaria Vaccine among Young African Children” N Engl J Med 2016; 374:2519-2529 10.1056/NEJMoa1515257

“Negative efficacy” and “rebound” are vaccine failure so bad that it is actually worse than never getting vaccinated in the first place; it is worse than “neutral” which would be no benefit but is actually evidence of people becoming more vulnerable to infection following vaccination—just like we have already noted with the pertussis vaccines.