Update for 2025: The videos originally posted to a single page titled “Vitamin D Goldmine” are being relocated/archived to their respective independent pages:
To get the full benefits of vitamin D, you have to (at least) optimize your vitamin D levels, as measured by the blood levels of 25-hydroxy-vitaminD3
Vitamin D Paradigm Shift summary: Vasquez 2025
Vitamin D combines with the vitamin D receptor (VDR) together functioning as a gene transcription factor directly binding to nuclear DNA and regulating the transcription of more than 1,000 genes or approximately 3% of the human genome.
For these reasons and others (such as its impact on the gut microbiome, neuroinflammation, mucosal/barrier defense, microbial/antiviral defense, mitochondrial performance, muscle function, immunomodulation/autoimmunity), we now appreciate that vitamin D is a keystone/cornerstone physiologic factor that impacts systemic health; deficiency of vitamin D therefore negatively impacts numerous body systems and can result in a wide range of disorders and diseases.
By now, we have clear evidence—both mechanistically and clinically—of the importance of vitamin D supplementation in the prevention and treatment of 1) chronic pain such as migraine, low-back pain [VIDEO], 2) depression and anxiety [VIDEO], 3) barrier defense against allergy and inflammation [VIDEO] , 4) vitamin D as anti-inflammation and immunomodulation [this current page; video above], 5) vitamin D against infections; vitamin D supports antiviral defense [VIDEO]
THE TASK THAT WAS GIVEN TO ME by the journal Alternative Therapies in Health and Medicine was to write an article about vitamin D; the catch was that I had to start from zero and had to have the article ready for publication within 8-10 days. This task was given to me, and I carried it forward with considerable success:
Vasquez A, Manso G, Cannell J. The clinical importance of vitamin D (cholecalciferol): a paradigm shift with implications for all healthcare providers. Altern Ther Health Med. 2004 Sep-Oct;10(5):28-36; quiz 37, 94. PMID: 15478784.
![[VIDEO] Vitamin D supplementation: "It's not what you take, it's what you make." Dr Alex Vasquez](https://substackcdn.com/image/youtube/w_728,c_limit/Q50_XQnTADs)
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