Microbiome and Dysbiosis Video #8: Dysbiosis by Location—Blood, Tissue, Parenchymal Dysbioses

We harbor bacteria and fungi living within our tissues as dysbiotic colonizations, not infections; this idea would have been impossible a few years ago but is now widely accepted by people in the know

Update 2025: All videos are being re-uploaded in Feb-May 2025 to provide direct and reliable access through the substack platform:

1. Microbiome Dysbiosis (1) Course Overview and Introduction to Major Concepts and Mechanisms

2. Microbiome Dysbiosis (2) Physiologic and Pathologic Mechanisms of Dysbiosis and Subclinical Microbial Colonizations (VIDEO:1hour,15minutes)

3. Microbiome Dysbiosis (3) Prototypes of Dysbiosis-Induced Disease (VIDEO:1hour,42minutes=102minutes)

4. Microbiome Dysbiosis (4) Conceptual Expansion Exploring Clinical Testing, Microbial Relevance and Irrelevance [VIDEO:1hour,18minutes=78minutes]

5. Microbiome Dysbiosis (5) Microbial Consequences in the Mouth, Oral Cavity [VIDEO:1hour,44minutes=104minutes]

6. Microbiome Dysbiosis (6) Microbial Imbalances in the Respiratory Tract and Sinuses [VIDEO:1hour,35minutes=95minutes]

7. Microbiome Dysbiosis (7) Dysbiosis by Location—Genitourinary Tract

8. Microbiome Dysbiosis (8) Dysbiosis by Location—Blood, Tissue, Parenchymal Dysbioses

9. Microbiome Dysbiosis (9) Dysbiosis by Location—Skin and Environmental Dysbiosis

10. MICROBIOME DYSBIOSIS (10) Gut Dysbiosis Prototypes and Solutions, part1, part2, part3, part4, part5

11. MICROBIOME DYSBIOSIS (11a) GUT-BRAIN AXIS and OPTIMAL DIET, Part 1 of 2 parts covering everything you need to know

12. MICROBIOME DYSBIOSIS (11b) GUT-BRAIN AXIS, Part 2 of 2

I am sure that even within the past 10 years, many clinicians and specialist professors (eg, Immunology, Microbiology, Pathology) would have considered the idea of living bacteria and fungi within the human body as part of the “normal condition” to be absurd, impossible, incompatible with life, and inconsistent with everything they knew.

“Surely”, they would say, “the immune system keeps the internal tissues and organs in a sterile state.” The common paradigm of common knowledge would also have them state that “microbial infiltration of tissues and blood would be accompanied by a robust inflammatory immune response, so that such microbial colonization would be eliminated and thus could never be part of the normal condition of either health nor disease. Microbial infiltration of blood is bacteremia or septicemia, and is always a pathologic condition. Microbial infiltration of tissues is always a localized destructive infection, presenting clinically as an obvious infection.”

That is what they would say, and they would be wrong.

By now, we know that not even the uterus is sterile, and that babies are born with bacteria and probably other microbes.

By now, we know that patients with (for example) pancreatic cancer have microbial (fungal) colonization of their pancreas gland which affects inflammatory and immune responses.

By now, we know that patients with inflammatory neurologic conditions have bacteria living within their brains, almost certainly contributing to their neuroinflammatory and neurodegenerative conditions.

By now we know that patients with obesity and diabetes have specific microbial signatures of living bacteria within their blood, and that these microbes contribute to the systemic inflammation and insulin resistance that characterize obesity and diabetes.

Update 2025: All videos are being re-uploaded in Feb-May 2025 to provide direct and reliable access through the substack platform:

1. Microbiome Dysbiosis (1) Course Overview and Introduction to Major Concepts and Mechanisms

2. Microbiome Dysbiosis (2) Physiologic and Pathologic Mechanisms of Dysbiosis and Subclinical Microbial Colonizations (VIDEO:1hour,15minutes)

3. Microbiome Dysbiosis (3) Prototypes of Dysbiosis-Induced Disease (VIDEO:1hour,42minutes=102minutes)

4. Microbiome Dysbiosis (4) Conceptual Expansion Exploring Clinical Testing, Microbial Relevance and Irrelevance [VIDEO:1hour,18minutes=78minutes]

5. Microbiome Dysbiosis (5) Microbial Consequences in the Mouth, Oral Cavity [VIDEO:1hour,44minutes=104minutes]

6. Microbiome Dysbiosis (6) Microbial Imbalances in the Respiratory Tract and Sinuses [VIDEO:1hour,35minutes=95minutes]

7. Microbiome Dysbiosis (7) Dysbiosis by Location—Genitourinary Tract

8. Microbiome Dysbiosis (8) Dysbiosis by Location—Blood, Tissue, Parenchymal Dysbioses

9. Microbiome Dysbiosis (9) Dysbiosis by Location—Skin and Environmental Dysbiosis

10. MICROBIOME DYSBIOSIS (10) Gut Dysbiosis Prototypes and Solutions, part1, part2, part3, part4, part5

11. MICROBIOME DYSBIOSIS (11a) GUT-BRAIN AXIS and OPTIMAL DIET, Part 1 of 2 parts covering everything you need to know

12. MICROBIOME DYSBIOSIS (11b) GUT-BRAIN AXIS, Part 2 of 2Reminders and refreshments regarding video technicalities

Peer-reviewed independently published articles related to this material provided by Dr Vasquez:

1. Dr Alex Vasquez. Mitochondrial Medicine Arrives to Prime Time in Clinical Care: Nutritional Biochemistry and Mitochondrial Hyperpermeability ("Leaky Mitochondria") Meet Disease Pathogenesis and Clinical Interventions. Integr Med (Encinitas) 2014 Aug;13(4):44-9 pubmed.ncbi.nlm.nih.gov/26770108

2. Dr Alex Vasquez. Reply to "role of Western diet in inflammatory autoimmune diseases" by Manzel et al. In current allergy and asthma reports (volume 14, issue 1, January 2014). Curr Allergy Asthma Rep2014 Aug;14(8):454. doi: 10.1007/s11882-014-0454-4 pubmed.ncbi.nlm.nih.gov/24947682

3. Dr Alex Vasquez. Neuroinflammation in fibromyalgia and CRPS is multifactorial. Nat Rev Rheumatol 2016 Apr;12(4):242. doi: 10.1038/nrrheum.2016.25 pubmed.ncbi.nlm.nih.gov/26935282

4. Dr Alex Vasquez. Biological plausibility of the gut-brain axis in autism. Ann N Y Acad Sci 2017 Nov;1408(1):5-6. doi: 10.1111/nyas.13516 pubmed.ncbi.nlm.nih.gov/29090837

5. Dr Alex Vasquez. Correspondence regarding Cutshall, Bergstrom, Kalish's "Evaluation of a functional medicine approach to treating fatigue, stress, and digestive issues in women" in Complement Ther Clin Pract 2016 May. Complement Ther Clin Pract 2018 May;31:332-333. doi: 10.1016/j.ctcp.2016.10.001 pubmed.ncbi.nlm.nih.gov/27814977

Dr Alex Kennerly Vasquez (introduction; brief Bio-CV) writes and teaches for an international audience on various topics ranging from leadership to nutrition to functional inflammology. Major books include Inflammation Mastery, 4th Edition (full-color printing, 1182 pages, equivalent to 25 typical books [averaging 60,000 words each]), which was also published in two separate volumes as Textbook of Clinical Nutrition and Functional Medicine (Volume 1: Chapters 1-4; Volume 2: Chapter 5—Clinical Protocols for Diabetes, Hypertension, Migraine, Fibromyalgia, Rheumatoid Arthritis, Psoriasis, Vasculitis, Dermatomyositis and most other major inflammatory/autoimmune disorders); several sections have been excerpted including Antiviral Strategies and Immune Nutrition (ISBN 1502894890) (aka, Antiviral Nutrition [available as PDF download] and Brain Inflammation in Chronic Pain, Migraine, and Fibromyalgia. Dr Vasquez’s books are available internationally via bookstores such as BookDepository, Amazon.com, Barnes and Noble, ThriftBooks, AbeBooks, BetterWorldBooks, WaterStonesBooks and his new Telegram channel is https://t.me/DrAlexVasquez.