COURSE INDEX Human Microbiome and Dysbiosis in Clinical Disease

Here we review and discuss the relationship between microbial colonizations of the human body and various states of health and disease

Update 2025: All videos are being re-uploaded in Feb-May 2025 to provide direct and reliable access through the substack platform:

1. Microbiome Dysbiosis (1) Course Overview and Introduction to Major Concepts and Mechanisms

2. Microbiome Dysbiosis (2) Physiologic and Pathologic Mechanisms of Dysbiosis and Subclinical Microbial Colonizations (VIDEO:1hour,15minutes)

3. Microbiome Dysbiosis (3) Prototypes of Dysbiosis-Induced Disease (VIDEO:1hour,42minutes=102minutes)

4. Microbiome Dysbiosis (4) Conceptual Expansion Exploring Clinical Testing, Microbial Relevance and Irrelevance [VIDEO:1hour,18minutes=78minutes]

5. Microbiome Dysbiosis (5) Microbial Consequences in the Mouth, Oral Cavity [VIDEO:1hour,44minutes=104minutes]

6. Microbiome Dysbiosis (6) Microbial Imbalances in the Respiratory Tract and Sinuses [VIDEO:1hour,35minutes=95minutes]

7. Microbiome Dysbiosis (7) Dysbiosis by Location—Genitourinary Tract

8. Microbiome Dysbiosis (8) Dysbiosis by Location—Blood, Tissue, Parenchymal Dysbioses

9. Microbiome Dysbiosis (9) Dysbiosis by Location—Skin and Environmental Dysbiosis

10. missing in action… but I am still searching: #10: Dysbiosis by Location—Gastrointestinal Dysbiosis

For best results, use the links provided above. You can still access the description below.

The Present: Listing of Videos Currently Available (and Coming Soon)

The video series outlined below extends from the book “Human Microbiome and Dysbiosis in Clinical Disease” (2015) which is included in the larger textbook Chapter 4 of Inflammation Mastery: Textbook of Clinical Nutrition and Functional Medicine.

Supporting/paid members/subscribers should bookmark this page and use it as the table of contents for the video materials and discussions. This page will be updated with new materials and hyperlinks especially during the summer of 2021.

1. Video #1 Introduction to Terminology and Concepts: Course Introduction & Clinical Impact of Microbial Molecules: Introduction to the human microbiome and dysbiosis; terms and definitions, clinical relevance and contextualization

2. Video #2 Pathophysiology: Physiologic and Pathologic Mechanisms of Dysbiosis

3. Video #3 Prototypes: Prototypic Clinical Patterns of Dysbiosis-Induced Disease

4. Video #4: Clinical Approach: Testing Microbes vs Treating Dysbiosis and How the Clinical Approach to Dysbiosis Differs from the Approach Used to Treat Infectious Disease

5. Video #5: Dysbiosis by Location—The Mouth

6. Video #6: Dysbiosis by Location—The Sinuses and Respiratory Tract

7. Video #7: Dysbiosis by Location—Genitourinary Tract

8. Video #8: Dysbiosis by Location—Blood, Tissue, Parenchymal Dysbioses

9. Video #9: Dysbiosis by Location—Skin and Environmental Dysbiosis

10. Video Series, Topic #10: Dysbiosis by Location—Gastrointestinal Dysbiosis

    1. Gut Dysbiosis 10.1 on Prototypes: 1 hour, 22 minutes

    2. Gut Dysbiosis 10.2 on Prototypes and Their Solutions: 2 hours

    3. Gut Dysbiosis 10.3 on Solutions: 38 minutes

    4. Gut Dysbiosis 10.4 on Solutions: 33 minutes

    5. Gut Dysbiosis 10.5 on Solutions: Final hour

    6. Gut Dysbiosis 10.6 on Solutions: added in 2020 specific to Gas, Bloating, IBS, and the Gut Microbiome Adaptation to a Healthier Diet (public access)

    7. Gut Dysbiosis 10.7 on Solutions: The Use of Antibiotic Drugs and Endocrine Interventions

11. Video #11: Gut-Brain Connection: Part 1—2 hours

12. Gut-Brain Connection: Part 2—2 hours (coming soon)

The Plan

I want you to know that I anticipate making a few updates to the Microbiome and Dysbiosis Course (and all of the courses, for that matter); so the courses aren’t “static” but will actually continue to be dynamic and move with the data and clinical science. The core information will remain the same—as it should—but we have a few more insights that are of actionable clinical value that warrant inclusion. Those will be added in text and video formats.

Samples of What is Coming Soon

The information I developed for this course was more than sufficient to support these publications, data from which came directly from the videos on gastrointestinal dysbiosis

1. Dr Alex Vasquez. Neuroinflammation in fibromyalgia and CRPS is multifactorial. Nat Rev Rheumatol 2016 Apr;12(4):242. doi: 10.1038/nrrheum.2016.25 pubmed.ncbi.nlm.nih.gov/26935282

2. Dr Alex Vasquez. Biological plausibility of the gut-brain axis in autism. Ann N Y Acad Sci 2017 Nov;1408(1):5-6. doi: 10.1111/nyas.13516 pubmed.ncbi.nlm.nih.gov/29090837

The Clinical Monograph

The video series outlined below extends from the book “Human Microbiome and Dysbiosis in Clinical Disease” (2015) which is included in the larger textbook Chapter 4 of Inflammation Mastery: Textbook of Clinical Nutrition and Functional Medicine.

Peer-reviewed independently published articles related to this material provided by Dr Vasquez

1. Dr Alex Vasquez. Mitochondrial Medicine Arrives to Prime Time in Clinical Care: Nutritional Biochemistry and Mitochondrial Hyperpermeability ("Leaky Mitochondria") Meet Disease Pathogenesis and Clinical Interventions. Integr Med (Encinitas) 2014 Aug;13(4):44-9 pubmed.ncbi.nlm.nih.gov/26770108

2. Dr Alex Vasquez. Reply to "role of Western diet in inflammatory autoimmune diseases" by Manzel et al. In current allergy and asthma reports (volume 14, issue 1, January 2014). Curr Allergy Asthma Rep 2014 Aug;14(8):454. doi: 10.1007/s11882-014-0454-4 pubmed.ncbi.nlm.nih.gov/24947682

3. Dr Alex Vasquez. Neuroinflammation in fibromyalgia and CRPS is multifactorial. Nat Rev Rheumatol 2016 Apr;12(4):242. doi: 10.1038/nrrheum.2016.25 pubmed.ncbi.nlm.nih.gov/26935282

4. Dr Alex Vasquez. Biological plausibility of the gut-brain axis in autism. Ann N Y Acad Sci 2017 Nov;1408(1):5-6. doi: 10.1111/nyas.13516 pubmed.ncbi.nlm.nih.gov/29090837

5. Dr Alex Vasquez. Correspondence regarding Cutshall, Bergstrom, Kalish's "Evaluation of a functional medicine approach to treating fatigue, stress, and digestive issues in women" in Complement Ther Clin Pract 2016 May. Complement Ther Clin Pract 2018 May;31:332-333. doi: 10.1016/j.ctcp.2016.10.001 pubmed.ncbi.nlm.nih.gov/27814977

Dr Alex Kennerly Vasquez (introduction; brief Bio-CV) writes and teaches for an international audience on various topics ranging from leadership to nutrition to functional inflammology. Major books include Inflammation Mastery, 4th Edition (full-color printing, 1182 pages, equivalent to 25 typical books [averaging 60,000 words each]), which was also published in two separate volumes as Textbook of Clinical Nutrition and Functional Medicine (Volume 1: Chapters 1-4; Volume 2: Chapter 5—Clinical Protocols for Diabetes, Hypertension, Migraine, Fibromyalgia, Rheumatoid Arthritis, Psoriasis, Vasculitis, Dermatomyositis and most other major inflammatory/autoimmune disorders); several sections have been excerpted including Antiviral Strategies and Immune Nutrition (ISBN 1502894890) (aka, Antiviral Nutrition [available as PDF download] and Brain Inflammation in Chronic Pain, Migraine, and Fibromyalgia. Dr Vasquez’s books are available internationally via bookstores such as BookDepository, Amazon.com, Barnes and Noble, ThriftBooks, AbeBooks, BetterWorldBooks, WaterStonesBooks and his new Telegram channel is https://t.me/DrAlexVasquez.